Professor James Uney

Research summary

Molecular, imaging and sophisticated viral delivery techniques are used to investigate the coding and non-coding genes that regulate neuronal function.  This work includes: (i) identifying the changes in gene expression that occur in neuronal cells exposed to stress or disease causing agent; (ii) developing viral vector systems optimized to study neuronal function; (iii) developing stem cell and induced pluripotent stem cell models of human disease conditions; (iv) how miRNAs and RNA binding proteins influence the expression of genes involved in the control of fundamental neuronal processes.

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Selected publications

• Regan, E, Uney, J, Dick, A, Zhang, Y, Nunez-Yanez, J, McGeehan, J, Claeyssens, F & Kelly, S 2010, ‘Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon’. Biomaterials, vol 31 (2)., pp. 207 - 215
• Kemp, K, Gordon, D, Wraith, D, Mallam, E, Hartfield, E, Uney, J, Wilkins, A & Scolding, N 2011, ‘Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells’. Neuropathology and Applied Neurobiology, vol 37., pp. 166 - 178

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Recent publications

• Szemes, M, Dallosso, AR, Melegh, ZB, Curry, TJ, Li, Y, Rivers, CA, Uney, JB, Magdefrau, A, Schwiderski, K, Park, J, Brown, KW, Shandilya, J, Roberts, SGE & Malik, KTA 2012, ‘Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A’. Human Molecular Genetics.
• Mastroyiannopoulos, N, Nicolaou, P, Anayasa, M, Uney, J & Phylactou, L 2012, ‘Down-regulation of myogenin can reverse terminal muscle cell differentiation’. PLoS One, vol 7(1)., pp. e29896 - e29896

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View complete publications list in the University of Bristol publications system