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Professor Jeremy Henley

Professor Jeremy Henley

Professor Jeremy Henley
BSc(Aston), PhD(Lond)

Professor of Molecular Neuroscience

Area of research

Neurotransmitter receptor trafficking in plasticity and disease

Office G.19a
Biomedical Sciences Building,
University Walk, Clifton BS8 1TD
(See a map)

+44 (0) 117 331 1945

Summary

Understanding the processes that dictate the distribution, maintenance and dynamics of neurotransmitter receptors is of fundamental importance to the molecular basis of fast excitatory transmission and synaptic.

The Henley lab is interested in the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from synapses under normal and stimulated conditions. Receptors share common biosynthetic and endocytic pathways but important specific differences allow selective regulation.

Increased understanding of the mechanisms of these processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.

In particular we focus on the roles of posttranslational modifications and protein-protein interactions at AMPA and kainate receptors.

To address these questions we use a wide range of molecular, biochemical, cell biology and imaging techniques including the use of viral transduction and fluorophore protein tagging technology to visualise the dynamics of receptor movement in living neurones in real time.

Activities / Findings

  • Molecular and functional characterisation of AMPA and kainate receptors
  • AMPA and kainate receptor trafficking, functional surface expression and recycling at synapses
  • Neuronal receptor trafficking in plasticity and disease
  • Neuronal receptor interacting proteins
  • Posttranslational modification in synapses
  • Role of SUMOylation in pre- and postsynaptic function
  • SUMOylation in neuronal disease

Teaching

Anatomical Sciences Year I: Lectures in Neuroscience Module. Year II: Lectures in Neuroscience Module & Neuroendocrinology Module; Year III: Neuroscience Option organizer, Lectures in Molecular Neurobiology Module & Basic Techniques Module

Keywords

  • Glutamate receptor
  • GABA
  • NSF
  • GluR2
  • Syntenin
  • GFP
  • AMPA receptor
  • PICK1
  • SUMOylation
  • SUMO

Skills

  • Brain ischaemia
  • epilepsy
  • drug addiction

Processes and functions

  • Learning and memory
  • development
  • synaptic transmission

Methodologies

  • Protein biochemistry
  • design & production of anti-peptide antibodies
  • molecular biology
  • in vitro translation
  • PCR
  • mutagenesis
  • mammalian cell expression systems
  • bacterial fusion proteins
  • yeast two-hybrid analysis protein
  • green fluorescent protein (GFP) imaging
  • confocal microscopy
  • co-immunoprecipitation
  • ELISA
  • cell surface biotinylation
  • subcellular fractionation
  • viral transfection
  • FLIP
  • FRAP
  • immunofluorescence
  • GST pull-down
  • recombinant protein expression
  • gel electrophoresis

Memberships

Organisations

School of Biochemistry

Other sites

Links

Selected publications

Read more >

Recent publications

View complete publications list in the University of Bristol publications system

Networks & contacts

  • Dr Laszlo Urban - Novartis - London
  • Dr Andrea Grant - Glaxo-Wellcome
  • Chris McBain - NIH and J-C. Lucaille - Montreal
  • Prof. Ole Peter Ottersen - Oslo
  • Drs Chrstophe Mulle and Daniel Choquet - Bordeaux
  • Members of MRC Centre - Bristol
  • Prof Jeremy Tavare Dept. of Biochemistry - Bristol

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