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Publication - Professor Jeremy Henley

    Exciting Times

    New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

    Citation

    Evans, A, Gurung, S, Henley, J, Nakamura, Y & Wilkinson, K, 2019, ‘Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors’. Neurochemical Research, vol 44., pp. 572-584

    Abstract

    Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

    Full details in the University publications repository