Dr Jon Brown

Research summary

Research details

Neurones are connected together in complex networks which allow for the storage and retrieval of information. However under certain conditions, these networks are compromised, resulting in deficits in memory and cognitive processing. For example, in Alzheimer’s disease there is significant neuronal loss which results in profound changes to the remaining neuronal network. In contrast in schizophrenia, another condition which results in significant cognitive impairment, there are more subtle alterations in synaptic connectivity between, and within, different brain areas.

The cellular and synaptic mechanisms underlying these changes to neuronal circuitry are not well understood. The goal of our ...

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Selected publications

• Brown, J, Chin, J, Leiser, S, Pangalos, M & Randall, A 2011, ‘Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease’. Neurobiology of Aging, vol 32(11)., pp. 2109.e1 - 2109.e14
• Brown, J & Randall, A 2009, ‘Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons’. Journal of Physiology, vol 587(6)., pp. 1265 - 1281

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Recent publications

• Brown, J, Hainsworth, AH, Stefani, A & Randall, AD 2013, ‘Whole-cell patch-clamp recording of voltage-sensitive ca(2+) channel currents in single cells: heterologous expression systems and neurones’. Methods in molecular biology (Clifton, N.J.), vol 937., pp. 123-48
• Nowacki, J, Osinga, H, Brown, J, Randall, A & Tsaneva-Atanasova, K 2011, ‘A unified model of CA1/3 pyramidal cells: An investigation into excitability’. Prog Biophys Mol Biol, vol 105(1-2)., pp. 34 - 48

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View complete publications list in the University of Bristol publications system