Dr Jonathan Hanley

Research summary

Learning and memory involves changes in the molecular machinery of synapses. AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain, and plasticity at excitatory synapses involves alterations in the number of AMPARs localised at the synaptic plasma membrane, brought about by regulated receptor trafficking.

AMPAR expression at the synaptic plasma membrane is regulated by endocytosis, exocytosis, recycling and lateral diffusion events that contribute to reductions (Long Term Depression, LTD) or increases (Long Term Potentiation, LTP) in synaptic strength. A number of protein interactions with AMPAR subunits have been identified that mediate these trafficking events

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Selected publications

• Dixon, R, Mellor, J & Hanley, J 2009, ‘PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose deprived hippocampal neurons’. The Journal of Biological Chemistry, vol 284., pp. 14230 - 14235
• Rocca, D, Martin, S, Jenkins, E & Hanley, J 2008, ‘Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis’. Nature Cell Biology, vol 10., pp. 259 - 271

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Recent publications

• Rocca, DL, Amici, M, Antoniou, A, Suarez, EMB, Halemani, ND, Murk, KT, McGarvey, J, Jaafari, N, Mellor, JR, Collingridge, GL & Hanley, JG 2013, ‘The small GTPase Arf1 regulates Arp2/3-mediated actin polymerization via PICK1 to control AMPA receptor trafficking, dendritic spine size and synaptic plasticity’. Neuron.
• Jaafari, N, Henley, JM & Hanley, JG 2012, ‘PICK1 Mediates Transient Synaptic Expression of GluA2-Lacking AMPA Receptors during Glycine-Induced AMPA Receptor Trafficking.’. The Journal of Neuroscience., pp. 11618-11630

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View complete publications list in the University of Bristol publications system