My research interests are the neural and cellular substrates of learning and memory processes in animals. I am specifically interested in the distinct contributions the perirhinal and prefrontal cortices and the hippocampal formation make to recognition memory processing.
The work conducted by my research group has involved the use of a number of complementary behavioural, and pharmacological techniques to examine the neural basis of recognition memory. In some of our recent experiments we have revealed that the perirhinal cortex, hippocampus and prefrontal cortex are differentially involved in specific components of recognition memory, namely familiairity discrimination (our ability to tell if a stimulus such as an object, is familiar or novel); object-in-place associaitive recognition memory (our ability to tell if an object has changed its location); recency recognition memory (our ability to judge how recently an object has been encountered) .
By infusing specific pharmacological antagonists directly into selected brain regions we have examined the role of distinct neurotransmitter systems including glutamate, acetylcholine and dopamine, and intracellular signalling pathways such as CaMK and MAK, in recognition memory. In addition we have used viral vectors to investigate the role of specific molecules such as CREB (in collaboration with Professor James Uney, Dept of Medicine).
View complete publications list in the University of Bristol publications system
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