Professor Pete Cullen

Research summary

Endosomal Sorting

The endosomal system comprises a series of functionally and morphologically heterogenous membrane compartments that are dynamically interconnected and function in the sorting and dispatching of cargo to specific cellular destinations. Following internalisation, receptors like those for the cation-independent mannose 6-phosphate (CI-MPR), transferrin (TfnR) and epidermal growth factor (EGFR) enter the early endosome from where a series of sorting events segregate them into separate trafficking iteniaries. The TfnR is recycled back to the plasma membrane either through a fast recycling route or, more slowly, via the juxtanuclear endocytic recycling compartment (ERC). In contrast, the EGFR is retained within the ...

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Selected publications

• Wassmer, T, Attar, N, Harterink, M, Weering, Jv, Traer, C, Oakley, J, Gould, B, Stephens, D, Verkade, P, Korswagen, H & Cullen, P 2009, ‘The retomer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network’. Developmental Cell, vol 17 (1)., pp. 110 - 122
• Bujny, M, Ewels, P, Humphrey, S, Attar, N, Jepson, M & Cullen, P 2008, ‘Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection’. Journal of Cell Science, vol 121 (12)., pp. 2027 - 2036

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Recent publications

• Hunt, SD, Townley, AK, Danson, CM, Cullen, PJ & Stephens, DJ 2013, ‘Microtubule motors mediate endosomal sorting by maintaining functional domain organization’. Journal of cell science.
• McGough, IJ & Cullen, PJ 2013, ‘Clathrin is not required for SNX-BAR-retromer mediated carrier formation’. Journal of cell science.

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View complete publications list in the University of Bristol publications system