Dr Zuner Bortolotto

Research summary

Understanding the mechanisms underlying basic functions of the brain, such as synaptic transmission and plasticity, is of fundamental importance to the molecular basis of neurological conditions affecting learning and memory and/or implicated in Alzheimer's disease and epilepsy. We are investigating the roles different receptor systems play in the control of plasticity and their relationship to epileptiform activity in the hippocampus.

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Selected publications

• Ceolin, L, Kantamneni, S, Barker, G, Hanna, L, Murray, L, Warburton, E, Robinson, E, Monn, J, Fitzjohn, S, Collingridge, G, Bortolotto, Z & Lodge, D 2011, ‘Study of Novel Selective mGlu2 Agonist in the Temporo-Ammonic Input to CA1 Neurons Reveals Reduced mGlu2 Receptor Expression in a Wistar Substrain with an Anxiety-Like Phenotype’. The Journal of Neuroscience, vol 31., pp. 6721 - 6731
• Bortolotto, Z & Collingridge, G 1992, ‘Activation of glutamate metabotropic receptors induces long-term potentiation’. Eur J Pharmacol, vol 214., pp. 297 - 298

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Recent publications

• Nicolas, CSC, Amici, M, Bortolotto, ZA, Doherty, AJ, Csaba, Z, Dournaud, P, Gressens, P, Collingridge, GL & Peineau, SAJ 2013, ‘The role of JAK-STAT signalling within the CNS’. JAK/STAT., pp. 1-10
• Collingridge, GL, Volianskis, A, Bannister, NJ, France, GM, Hanna, L, Mercier, MS, Tidball, PJ, Fang, GY, Irvine, MW, Costa, B, Monaghan, D, Bortolotto, ZA, Molnar, E, Lodge, D & Jane, DE 2013, ‘The NMDA receptor as a target for cognitive enhancemant’. Neuropharmacology, vol 64., pp. 13-26

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View complete publications list in the University of Bristol publications system