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Publication - Dr Ginny Gould

    Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

    Citation

    Gould, VC, Okazaki, A & Avison, MB, 2013, ‘Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.’. Antimicrobial Agents and Chemotherapy, vol 57., pp. 655-657

    Abstract

    A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.

    Full details in the University publications repository