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Comparative biomechanical

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Mechanical loading is the primary functional influence on bone mass and architecture. This influence is exerted by bone cells responding to the strains engendered by functional loading within bone tissue. Increased strain-related stimulation results in increased bone formation and decreased stimulation in bone resorption. With age this strain-related regulation fails, bone mass declines and fracture incidence increases. The lifetime risk of a fragility fracture in  women is 53.2% and men 20.7%.

The Price lab investigates the mechanisms linking functional strain to bone (re)modelling by assessing the osteo-regulatory responses to short periods of dynamic load in mouse bones  in vivo and in cell culture models  ex vivo.   Current projects are studies including the effects of ageing on the adaptive response, interactions between the estrogen receptor and other signaling pathways and the epigenetic regulation of the adaptive response.