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Dr Nicolas Granger

Dr Nicolas Granger

Dr Nicolas Granger
DMV, PhD, DipECVN

Research Fellow

Area of research

Large animal models for neurological diseases

Langford House,
Langford, Bristol BS40 5DU
(See a map)

+44 (0) 117 331 9113

Biography

 

I have recently been awarded a Translational Neuroscience Research Fellowship from the Institute for Advanced Studies from the University of Bristol (http://www.bristol.ac.uk/ias/).

Activities / Findings

My profile:

Neuroscientist / clinical neurologist.

Field of research: spinal cord injury, cellular therapies, translational / regenerative medicine.

My carreer path:

I graduated from the National Veterinary School of Alfort, France, in 2002, where I also completed an internship in 2003 and then a neurology / neurosurgery training from 2003 to 2006. At this time I was also taking part in research on muscular dystrophy affecting dogs and humans and participated in a trial testing mesoangioblast cell therapy to correct this disease. I became a Diplomate of the European College of Veterinary Neurology in October 2006.

I moved to the United Kingdom, at the Queen’s Veterinary School Hospital, University of Cambridge, where I practiced as a clinical neurologist from 2006 to 2008, running the neurology / neurosurgery service. I then took a research position in neuroscience in Cambridge, which allowed me to obtain a PhD in neurosciences in 2012.

I joined the University of Bristol in September 2012, as a senior lecturer in small animal neurology, which involves teaching neurology, clinical work on our neurological / neurosurgical canine and feline cases and research in neuroscience.

My research interests:

My research focuses on the development of new tehrapuetic strategies for spinal cord injury in dogs and humans. I tested the efficacy of a cell therapy for paraplegic dogs, which constitute an avenue for treating similar injuries in people.  During my PhD, I conducted a clinical trial in domestic dogs with irreversible spinal cord injury and chronic paraplegia, in which we demonstrated that autologous spinal cord transplantation of canine olfactory ensheathing cells has strong positive effects on locomotion.  Olfactory ensheathing cells form a major natural cell transplant population with a well-established role in nerve guidance and support during regeneration. To demonstrate efficacy of new treatments, I use kinematic, urodynamic and electrophysiological methods. I also work on the development of neuro-prosthesis to treat urinary incontinence in paraplegic dogs.

Current projects on spinal cord injury treatment involve the use of new molecules (such as chondroitnase ABC or DRP-3) in combination with olfactory ensheathing cells and neuroprosthesis. Repair of the spinal cord and restoration of the neurological function might be achived by combining a biological appraoch with biomedical engineering.

Research in veterinary neurology:

I am leading research on inherited peripheral nerve diseases in companion animals, taking advantage of next-generation sequencing tools (such as single nucleotide polymorphism genotyping array and the sequenced dog genome). This apporach is useful to identify the molecular defects underlying inherited peripheral nerve diseases in dogs, sometimes with very small number of affected individuals. This promises to lead to an exponential unraveling of genetic mutations in animals spontaneously affected by suspected genetic diseases.

Main diseases I have been investigating are:

- Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) in Black Russian Terriers (see:http://www.caninegeneticdiseases.net/JLPP/)

- Demyelinating polyneuropathy in Miniature Schnauzers 

 

Keywords

  • Neurology
  • neuroscience
  • spinal cord injury
  • cellular therapy
  • animal model
  • translational research

Skills

  • spinal cord injury
  • inherited peripheral nerve diseases

Processes and functions

  • trauma

Methodologies

  • animal model
  • kinematic
  • electrophysiology
  • urodynamic

Recent publications

View complete publications list in the University of Bristol publications system

Courses

Dr Granger currently teaches 2 courses:

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