Browse/search for people

Publication - Dr Nicolas Granger

    Degenerative encephalopathy in Nova Scotia Duck Tolling Retrievers presenting with a rapid eye movement sleep behavior disorder


    Barker, EN, Dawson, LJ, Rose, J, Van Meervenne, S, Frykman, O, Rhodin, C, Leijon, A, Soerensen, KE, Järnegren, J, Johnson, GC, O'Brien, DP & Granger, N, 2016, ‘Degenerative encephalopathy in Nova Scotia Duck Tolling Retrievers presenting with a rapid eye movement sleep behavior disorder’. Journal of Veterinary Internal Medicine, vol 30., pp. 1681?1689


    Background: Neurodegenerative diseases are a heterogeneous group of disorders characterized by loss of neurons, and are commonly associated with a genetic mutation.

    Hypothesis/Objectives: To characterize the clinical and histopathological features of a novel degenerative neurological disease affecting the brain of young adult Nova Scotia Duck-Tolling Retrievers (NSDTR).

    Animals: Nine, young adult, related, NSDTR were evaluated for neurological dysfunction and rapid eye movement sleep behavior disorder.

    Results: Clinical signs of neurological dysfunction began between two months and five years of age, and were progressive in nature. They were characterized by episodes of marked movements during sleep, increased anxiety, noise phobia, and gait abnormalities. Magnetic resonance imaging documented symmetrical, progressively increasing, T2-weighted image intensity, predominantly within the caudate nuclei, most consistent with necrosis secondary to grey matter degeneration. Clinicopathological analysis of blood and cerebrospinal fluid, infectious disease screening and urine metabolite screening were unremarkable in most cases. Post-mortem examination of brain tissue identified symmetrical malacia of the caudate nuclei and axonal dystrophy within the brainstem and spinal cord. Genealogical analysis supports an autosomal recessive mode of inheritance.

    Conclusions and Clinical Importance: A degenerative encephalopathy was identified in young adult NSDTRs that we suspect is a hereditary disease. The prognosis is guarded due to the progressive nature of the disease, which is minimally responsive to empirical treatment.

    Full details in the University publications repository