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Professor Andrew Dowsey

Professor Andrew Dowsey

Professor Andrew Dowsey
MEng(Lond.), PhD

Chair in Population Health Data Science

Office Room 1.04
Dolberry Building,
Langford, Bristol BS40 5DU
(See a map)

+44 (0) 117 33 10051

Summary

My research concerns the combination of bioinformatics and biostatistics approaches to integrate disparate data sources for medical and veterinary research. We are experienced with handling modalities including quantitative omics data (transcriptomics, proteomics, metabolomics), medical images (MRI, CT, PET, Ultrasound) and pervasive sensing/biosensing data, together with clinical metadata. I also lead a research programme focussed on new computational methodology for biological mass spectrometry. We are building statistical methodology that operates from sensor readings to biological processes, together with approaches for visualisation and quality control of the raw data and results. For more information please visit my Research Group website.

Current Grants

Sole Investigator, A holistic statistical modelling approach to quantitative discovery proteomics and metabolomics for underpinning integrative systems medicine, MRC Methodology New Investigator Research Grant MR/L011093/1.

Principal Investigator, Bayesian quantitative proteomics, Bilateral NSF/BIO-BBSRC Project Grant BB/M024954/1.

Principal Investigator, Delivering a production platform and atlas for next-generation biomarker discovery, validation and assay development in clinical proteomics, MRC Methodology Project Grant MR/N028457/1.

Co-Principal Investigator, Multi-dimensional visualisation and annotation platform for mass spectrometry, BBSRC Follow on Fund Grant BB/N012534/1.

Co-Investigator, Elucidation of molecular mechanisms underpinning disease initiation and progression in age-related macular degeneration, Fight for Sight Project Grant.

Previous Grants

Sole Investigator, High-throughput differential expression proteomics, EPSRC Overseas Fellowship at the Life Sciences Interface EP/E03988X/1.

Principal Investigator, Unifying metabolome and proteome informatics, BBSRC TRDF2 Grant BB/L018616/1.

Principal Investigator, Streaming 3D visualisation platform for raw and analysed data from proteomics and metabolomics repositories, BBSRC TRDF2 Grant BB/K016733/1.

Principal Investigator, Signal-based image registration and mixed modelling for differential analysis of large scale cross-omics datasets, BBSRC TRDF2 Grant BB/K004158/1. 

Co-Principal Investigator, ProteoFormer - a software toolkit for top-down proteomics, BBSRC TRDF2 Grant BB/L018454/1.

Co-Investigator, Time course of development of diabetic nephropathy and its reversal by copper chelation, MRC Project Grant MRC MR/L010445/1.

Co-Investigator, Molecular dissection of human Alzheimer's Disease, Alzheimer's Research UK Pilot Grant.

Biography

Andrew Dowsey is Chair of Population Health Data Science at the University of Bristol, a joint post between the Department of Population Health Sciences and Bristol Veterinary School, where he is Research Director for Bristol Veterinary School. His data science expertise lies at the interface of health sciences and engineering, having previously held positions in the Department of Computing and Institute of Biomedical Engineering, Imperial College London (EPSRC Postdoctoral Fellowship), the Institute of Human Development, University of Manchester (Lecturer), and the Department of Electrical Engineering and Electronics, University of Liverpool (Reader), together with visiting appointments at the University of Texas MD Anderson Cancer Centre and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin.

Activities / Findings

Please see my Research Group website.

Skills

  • Infectious disease

Methodologies

  • Proteomics
  • Bayesian and MCMC models

Recent publications

View complete publications list in the University of Bristol publications system

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