Unit information: Coronary Artery Disease II in 2020/21

Unit name	Coronary Artery Disease II
Unit code	SOCSM0004
Credit points	20
Level of study	M/7
Teaching block(s)	Academic Year (weeks 1 - 52)
Unit director	Professor. George
Open unit status	Not open
Pre-requisites	None
Co-requisites	None
School/department	Bristol Medical School
Faculty	Faculty of Health Sciences

Description including Unit Aims

This unit will expand on Unit 3 and provide further information and detail with regards to coronary artery disease. The current surgical interventions used for coronary artery disease (CABG and stent implantation) will be described, as well as the pathobiology of the numerous clinical complications that frequently occur as a result of these procedures, including neointima formation, thrombosis, cardioplegia, kidney and neurological damage. This unit’s main aim is to highlight the need for improved interventional treatments for coronary artery disease and the consequent value that pre-clinical (animal and in-vitro) models have in assessing the effectiveness of new therapeutic approaches. Finally, emerging new approaches that have been evaluated at the pre-clinical level for the treatment of coronary artery disease, such as the use of stem cells, altered stent coatings, novel clinical pharmacology approaches, micro-RNAs and gene therapy will be discussed.

Intended Learning Outcomes

Students successfully completing this module will be able to:

• Discuss the currently used clinical treatments (surgical interventions) for coronary artery disease.
• Outline the clinical problem of complications after treatment of coronary artery disease with CABG, PTCA or stents
• Understand the pathobiology of the complications that occur after surgical interventional treatment for coronary artery disease.
• Recognize the various pre-clinical models that are utilized for the assessment of new and emerging therapeutic approaches for the treatment of coronary artery disease.

Teaching Information

• Synchronous and asynchronous lectures; tutorials
• Online discussion forum(s)
• Self-directed study
• Practical workshops which will take place in Bristol if possible or will be taught in an alternative online format

Assessment Information

Coursework (contributing a total of 60% to the unit) consisting of:

• 4 sets of multiple choice questions (MCQs) of a simple format (select the best answer from 4 or 5 options), contributing 10% to the unit.
• 1 essay (1500 words), contributing 25% to the unit.
• 1 short answer (750 words), contributing 12.5% to the unit.
• Scientific abstract of a unit relevant paper, contributing 12.5% to the unit.

Please note that students will be given formative feedback on all coursework assessment.

Written exams (contributing a total of 40% to the unit) consisting of:

• Essay paper contributing 40% to the unit.

Reading and References

Epstein AJ, Polsky D, Yang F, Yang L, Groeneveld PW. Coronary revascularization trends in the United States, 2001-2008. JAMA. 2011;305(17):1769-76.

Suzuki Y, Yeung AC, Ikeno F. The pre-clinical animal model in the translational research of interventional cardiology. JACC Cardiovasc Interv. 2009;2(5):373-83.

Madonna R, De Caterina R.Stem cells and growth factor delivery systems for cardiovascular disease. J Biotechnol. 2011;154(4):291-7.

Mariani JA, Kaye DM. Delivery of gene and cellular therapies for heart disease. J Cardiovasc Transl Res. 2010;3(4):417-26.

Synetos A, Toutouzas K, Karanasos A, Stathogiannis K, Triantafyllou G, Tsiamis E, Lerakis S, Stefanadis C. Differences in drug-eluting stents used in coronary artery disease. Am J Med Sci. 2011 Nov;342(5):402-8.