Unit name | Coronary Artery Disease II |
---|---|
Unit code | SOCSM0004 |
Credit points | 20 |
Level of study | M/7 |
Teaching block(s) |
Academic Year (weeks 1 - 52) |
Unit director | Professor. George |
Open unit status | Not open |
Pre-requisites |
None |
Co-requisites |
None |
School/department | Bristol Medical School |
Faculty | Faculty of Health Sciences |
This unit will expand on Unit 3 and provide further information and detail with regards to coronary artery disease. The current surgical interventions used for coronary artery disease (CABG and stent implantation) will be described, as well as the pathobiology of the numerous clinical complications that frequently occur as a result of these procedures, including neointima formation, thrombosis, cardioplegia, kidney and neurological damage. This unit’s main aim is to highlight the need for improved interventional treatments for coronary artery disease and the consequent value that pre-clinical (animal and in-vitro) models have in assessing the effectiveness of new therapeutic approaches. Finally, emerging new approaches that have been evaluated at the pre-clinical level for the treatment of coronary artery disease, such as the use of stem cells, altered stent coatings, novel clinical pharmacology approaches, micro-RNAs and gene therapy will be discussed.
Students successfully completing this module will be able to:
Coursework (contributing a total of 60% to the unit) consisting of:
Please note that students will be given formative feedback on all coursework assessment.
Written exams (contributing a total of 40% to the unit) consisting of:
Epstein AJ, Polsky D, Yang F, Yang L, Groeneveld PW. Coronary revascularization trends in the United States, 2001-2008. JAMA. 2011;305(17):1769-76.
Suzuki Y, Yeung AC, Ikeno F. The pre-clinical animal model in the translational research of interventional cardiology. JACC Cardiovasc Interv. 2009;2(5):373-83.
Madonna R, De Caterina R.Stem cells and growth factor delivery systems for cardiovascular disease. J Biotechnol. 2011;154(4):291-7.
Mariani JA, Kaye DM. Delivery of gene and cellular therapies for heart disease. J Cardiovasc Transl Res. 2010;3(4):417-26.
Synetos A, Toutouzas K, Karanasos A, Stathogiannis K, Triantafyllou G, Tsiamis E, Lerakis S, Stefanadis C. Differences in drug-eluting stents used in coronary artery disease. Am J Med Sci. 2011 Nov;342(5):402-8.