Please note: Due to alternative arrangements for teaching and
assessment in place from 18 March 2020 to mitigate against the restrictions in
place due to COVID-19, information shown for 2019/20 may not always be accurate.
Please note: you are viewing unit and programme information
for a past academic year. Please see the current academic year for up to date information.
| Unit name |
The Dynamic Proteome |
| Unit code |
BIOC30604 |
| Credit points |
20 |
| Level of study |
H/6
|
| Teaching block(s) |
Teaching Block 1 (weeks 1 - 12)
|
| Unit director |
Professor. Mike Jones |
| Open unit status |
Not open |
| Pre-requisites |
BIOC20002 and BIOC20001
|
| Co-requisites |
None
|
| School/department |
School of Biochemistry |
| Faculty |
Faculty of Life Sciences |
Description including Unit Aims
Students study advanced topics in protein biochemistry through a series of 24 lectures. These lectures are split into two elements. The first element, Structure and Dynamics of Biomolecules and Systems, covers techniques used to analyse protein structure and dynamics. The second element, Protein Assembly, looks at how proteins are synthesized and how they fold into their unique 3 dimensional shapes.
Aims:
Structure and Dynamics of Biomolecules and Systems
- The techniques used to study protein structure
- The study of kinetics in enzymes and chemiosmotic systems
- The techniques to study protein dynamics on femtosecond to hour scales
- The synthesis of proteins by the ribosomes
Protein Assembly
- Protein structure from bonds to macromolecular complexes
- Sequence to structure relationships and protein folding pathways
- The insertion of peptides and proteins into membranes
Intended Learning Outcomes
- An in-depth knowledge and understanding of the advanced protein biochemistry topics covered in the unit and an ability to keep abreast with recent developments in the field.
- The ability to gather information from the primary scientific literature and to critically evaluate the material and appraise competing theories.
- An understanding of the importance of the study of protein structure and dynamics and an understanding of the experimental tools used to study them.
- An understanding of reaction kinetics and the experimental tools used in the study of kinetics.
Teaching Information
Lectures.
Assessment Information
Assessment for learning (formative)
Students will undertake the following mock assessment exercises:
- a mock exam essay
- a mock MCQ test
Assessment of learning (summative)
The unit will be assessed as follows:
- 20% a 1 hour MCQ test. Students will be given 2 research papers to read in advance of the test. The test will consist of a series of MCQ questions which test the students’ understanding of the material in the research articles. The test will be an “open book exercise”, i.e. the research papers will be given to students in the exam.
- 80% a 2 hour examination in January. Students will be given a choice of essay titles and will be expected to answer 2 questions. The essay marks will be moderated by a second independent marker.
Reading and References
Reviews and primary articles from the current scientific literature.
