| Unit name | Introduction to Renal Sciences |
|---|---|
| Unit code | BRMSM0031 |
| Credit points | 20 |
| Level of study | M/7 |
| Teaching block(s) |
Teaching Block 1 (weeks 1 - 12) |
| Unit director | Dr. Becky Foster |
| Open unit status | Not open |
| Pre-requisites |
None |
| Co-requisites |
None |
| School/department | Bristol Medical School |
| Faculty | Faculty of Health Sciences |
This unit will be a combination of taught lectures, practical demonstrations and facilitated case-based tutorials to give co-ordinated, deep learning around renal sciences based on the intended leaning outcomes below.
i. To give an overview of the structure and function of the kidney
ii. To describe how renal function is measured clinically and how it can be influenced by disease
iii. To apply understanding of how renal function can be measured experimentally
iv. To integrate knowledge of renal function to understand how it can regulate body homeostasis
v. Appraise the current research advances in this area
Coursework (total 50%)
10min oral presentation (15%),
assessed performance (10%) including critical analysis, depth and breadth of self directed learning.
This will be assessed by two tutorial facilitators using the same marking structure.
Exam (total 50%)
1. A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli. Sara Desideri, Karen L. Onions, Yan Qiu, Raina Ramnath, Matthew J. Butler Chis R. Neal, Matthew L. R. King, Andrew E. Salmon, Moin A. Saleem, Gavin I. Welsh, C. Charles Michel, Simon C. Satchell, Andrew. H. J. Salmon and Rebecca R. Foster. Kidney Int. 2018 May;93(5):1086-1097.
2. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJ. Cell Metab. 2010 Oct 6;12(4):329-40.
3. Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management. Bierzynska A, McCarthy HJ, Soderquest K, Sen ES, Colby E, Ding WY, Nabhan MM, Kerecuk L, Hegde S, Hughes D, Marks S, Feather S, Jones C, Webb NJ, Ognjanovic M, Christian M, Gilbert RD, Sinha MD, Lord GM, Simpson M, Koziell AB, Welsh GI, Saleem MA.Kidney Int. 2017 Apr;91(4):937-947.
4. What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium? Satchell SC, Tooke JE. Diabetologia. 2008 May;51(5):714-25.
5. Mouse models to study kidney development, function and disease. Ly JP, Onay T, Quaggin SE. Curr Opin Nephrol Hypertens. 2011 Jul;20(4):382-90.
