Unit name | Coronary Artery Disease I |
---|---|
Unit code | SOCSM0003 |
Credit points | 20 |
Level of study | M/7 |
Teaching block(s) |
Academic Year (weeks 1 - 52) |
Unit director | Professor. Johnson |
Open unit status | Not open |
Pre-requisites |
None |
Co-requisites |
None |
School/department | Bristol Medical School |
Faculty | Faculty of Health Sciences |
This unit will introduce the clinical problem of coronary artery disease. It will provide an overview of the methods currently utilised for patient diagnosis and assessment of disease severity (from GP to clinic), such as ECG, angiogram, imaging (IVUS, PET) and biomarkers. The unit will provide a detailed overview of the underlying pathobiology of atherosclerosis including endothelial cell dysfunction, inflammation, smooth muscle cell proliferation, migration and apoptosis, plaque rupture, thrombosis and vessel occlusion. Furthermore, it will discuss the impact of genomics on cardiovascular disease, common risk factors (including hypercholesterolemia, hypertension, diabetes, smoking), and its epidemiology. Finally, this unit will outline the currently used drug treatments for coronary artery disease.
Students successfully completing this unit will be able to:
Provide an overview of relevant ‘clinical pharmacology’ and the current pharmacological treatments used for coronary artery disease patients
Coursework (contributing a total of 60% to the unit) consisting of:
Please note that students will be given formative feedback on all coursework assessment.
Written exams (contributing a total of 40% to the unit) consisting of:
Fishbein, MC, The vulnerable and unstable atherosclerotic plaque. Cardiovascular Pathology;19(1):6-11.
Farb, A, AP Burke, AL Tang, Y Liang, P Mannan, J Smialek, R Virmani, Coronary Plaque Erosion Without Rupture Into a Lipid Core : A Frequent Cause of Coronary Thrombosis in Sudden Coronary Death. Circulation, 1996;93(7):1354-1363.
Alsheikh-Ali, AA, GD Kitsios, EM Balk, J Lau, S Ip, The Vulnerable Atherosclerotic Plaque: Scope of the Literature. Annals of Internal Medicine, 2010;153(6):387-W149.
Libby, P, Inflammation in atherosclerosis. Nature, 2002;420:868-874.
Libby, P, Y Okamoto, VZ Rocha, E Folco, Inflammation in Atherosclerosis: Transition From Theory to Practice. Circulation Journal, 2010;74(2):213-220.
Toutouzas, K, M Drakopoulou, I Skoumas, C Stefanadis, Advancing therapy for hypercholesterolemia. Expert Opinion on Pharmacotherapy, 2010;11(10):1659-1672.