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Unit information: Pathology of Transfusion and Transplantation Science (TTS-A2) in 2020/21

Unit name Pathology of Transfusion and Transplantation Science (TTS-A2)
Unit code PANMM0017
Credit points 20
Level of study M/7
Teaching block(s) Teaching Block 2 (weeks 13 - 24)
Unit director Dr. Mallinson
Open unit status Not open




School/department School of Cellular and Molecular Medicine
Faculty Faculty of Life Sciences


This Unit gives an overview of immunology and discusses the pathological mechanisms involved in haematological disease.


To provide a grounding in immunology-essential for this Unit and for the clinical transfusion and transplantation Unit.

To explain the mechanisms of red cell destruction by antibodies

To enable the students to identify antibodies

The teach the pathology of haemolytic anaemias, haemoglobinopathies, haemolytic disease of the newborn and the corresponding effects of platelet antibodies.

To explain platelet defect and defects in clotting such as haemophilia.

Laboratory tests and patient treatments are discussed for all the above

For the students to have an appreciation of the relationship between blood groups and disease.

Intended learning outcomes

Upon completion of the Unit students should have:

1. A good level of knowledge of immunology and its relevance to transfusion and transplantation

2. A broad and in depth understanding of the physiology and pathological mechanisms that apply to the discipline as listed above;

should be able to :

3. Show originality in the discussion and synthesis of information

4. Deal with complex issues systematically and creatively for example by answering an exam question requiring information from several lectures.

5. Critically evaluate current research in the discipline

6. Demonstrate comprehension of scientific literature at the forefront of the discipline

7. Demonstrate independent learning ability following lectures and tutorials

The above are assessed as follows:

Short exam questions 1,2

Exam essay questions 1,2,3,4,6,7

Assignment 3,4,5,6,7

Teaching details

Lectures and tutorials NB contact hours below refers to approximately 11 per week for 4 weeks

Assessment Details

One 2000 word assignment (30% of Unit marks)

One 2 ½ hour exam with a section of short answers (approx ½ hour, 20% of Unit marks) and two essays (approx 2hr, 50% of Unit marks).

The essay section of the exam paper has been deemed a must-pass component requiring a pass mark of at least 50%.

Reading and References

Practical Transfusion Medicine 4th edition (eds Murphy, Pamphilon,Heddle) Wiley –Blackwell

Essential Haematology 6th edition Hoffbrand & Moss. Wiley-Blackwell

Janeway’s Immunobiology 8th edition Murphy. Garland Science

Essentials of Immunohematology Flynn jr . Saunders

Alloimmune disorders of pregnancy (eds Hadley & Soothill) . Cambridge University Press