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Unit information: Provision of Blood, Cells, Tissues and Organs (TTS-B1) in 2018/19

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Unit name Provision of Blood, Cells, Tissues and Organs (TTS-B1)
Unit code PANMM0018
Credit points 20
Level of study M/7
Teaching block(s) Teaching Block 1 (weeks 1 - 12)
Unit director Mr. Bullock
Open unit status Not open
Pre-requisites

None

Co-requisites

None

School/department School of Cellular and Molecular Medicine
Faculty Faculty of Life Sciences

Description

This Unit gives an overview of the regulatory aspects and logistics of obtaining material for transfusion and transplantation. It also covers storage and testing of these materials.

Aims:

To introduce the role of GMP and quality into transfusion and transplantation

To explain the different types of donor and consent for donation.

To understand donor selection and their donation motives of blood donors.

To discuss blood component preparation and storage and any new developments in component production.

To explain the concept of tissue and cell banking.

To teach the principles of microbiological testing of materials for transfusion and transplantation and how positive results are followed up.

To discuss pathogen reduction strategies in donated material.

To teach the biochemical changes that occur during storage/transport of material.

To discuss the working of a large organisation.

The Unit also covers stem cell assays and HLA typing methods of cells and organs.

For students to study a current aspect of transfusion microbiology or component preparation in depth.

To develop high level writing and appraisal skills

Intended learning outcomes

Upon completion of the Unit students should have:

1. A broad and in depth understanding of blood, cell, tissue and organ collection and donation including GMP and quality issues

2. A broad and in depth understanding of donor selection and testing of donated material

And should be able to :

3. Discuss the concepts of processing and storage of donated material and biochemical changes that occur

4. Explain the methods used for pathogen reduction in donated material and their effectiveness

5. Understand the logistics of donation and testing and the impact of change in a large organisation

6. Evaluate new methodologies and develop critiques of them

7. Show a critical awareness of current problems such as Hepatitis E and other current research in the discipline

8. Deal with complex issues systematically and creatively

9. Demonstrate independent learning ability and originality in the discussion and synthesis of information

10. Communicate with specialist and non specialist audiences (eg general public) using a variety of writing styles

11. Demonstrate creative use of word processing packages

The above are assessed as follows:

Short exam questions 1,2,3,4

Exam essay questions 1,2,3,4,5,6,7,8,9

Assignment 5,6,7,8,9,10,11

Teaching details

Lectures and tutorials NB contact hours below are 11 per week for 4 weeks

Assessment Details

One 2000 word assignment (30% of Unit marks)

One 2 ½ hour exam with a section of short answers (approx ½ hour, 20% of Unit marks) and two essays (approx 2hr, 50% of Unit marks).

The essay section of the exam paper has been deemed a must-pass component requiring a pass mark of at least 50%

Reading and References

Transfusion Microbiology, (Eds Barbara, Regan Contreras). Cambridge Press

ABC of Transfusion 4th edition (Ed Contreras). Wiley-Blackwell

AABB Technical Manual 17th edition Roback,Grossman& Hillyer. AABB

The “Orange” Guide. MHRA Rules and Guidance for Pharmaceutical Manufacturers & Distributors 2007. Pharmaceutical Press.

Practical Transfusion Medicine 4th edition (eds Murphy, Pamphilon,Heddle). Wiley –Blackwell

Essentials of Tissue Banking (ed Galea). Springer

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