Unit information: Special Organic & Biological Chemistry in 2020/21

Unit name	Special Organic & Biological Chemistry
Unit code	CHEMM0006
Credit points	20
Level of study	M/7
Teaching block(s)	Teaching Block 4 (weeks 1-24)
Unit director	Professor. Wyatt
Open unit status	Not open
Pre-requisites	CHEM30011 or CHEM30001 or CHEM30002 or CHEM30003
Co-requisites	None
School/department	School of Chemistry
Faculty	Faculty of Science

Description including Unit Aims

This unit develops the organic chemistry given in CHEM30011 and expands that essential base of organic chemistry into a more advanced level of study and extends into specialist/cutting edge areas. The unit covers several core areas of the subject, as well as introducing some more specialised areas at the frontier of current research.

This unit aims to provide a deepening understanding and widening knowledge of the chemistry of the carbon, which is appropriate for a final year MSci student and will enable progress to even more specialised aspects in a variety of areas of organic chemistry. The implications of these ideas are illustrated with real world examples to set them in context and highlight their relevance in the modern scientific world. The unit aims to explore key reactivity and applications in new areas of chemistry which build upon and broaden concepts introduced in the second and third year.

Intended Learning Outcomes

• Understand how kinetics and thermodynamics can be investigated
• Understand how multi-dimensional NMR may be applied to large biological systems
• Explain the use of modern NMR in the pharmaceutical industry
• Devise strategies for the total synthesis of more complex organic molecules
• Recognise and apply a variety of methods used in asymmetric synthesis
• Apply modern approaches of biological chemistry to design experiments for the elucidation of enzyme mechanism and kinetics.

Teaching Information

Teaching will be delivered through a combination of synchronous and asynchronous sessions, including lectures and masterclasses (interactive seminar sessions of the whole class) and independent study, supported by drop-in sessions, problem sheets and self-directed exercises. The Dynamic Laboratory Manual provides important e-learning resource in advance of workshop sessions.

Assessment Information

Assessment of learning/Summative assessmsent End-of-unit timed, open-book Examination (100%)

Reading and References

Essential reading will be from the following books:

Organic Chemistry, 2^nd Edition, J Clayden, N. Greeves, S Warren, Oxford University Press, 2012.

Further reading will be from the following books:

Organic Synthesis: Strategy & Control, P Wyatt and S Warren (Wiley, 2007); Heterocyclic chemistry, 5th edition, JA joule and K Mills, Chapman and Hall, 2010; Supramolecular Chemistry 2nd edition, JW Steed and JL Atwood, Wiley, 2009; Marchs advanced organic chemistry: reactions, mechanisms and structure, 6th edition, MB Smith and J F March, Wiley, 2007; An NMR primer for life scientists, H. Rattle, Partnership Press, 2001; Asymmetric synthesis, Eds RA Aitken and SN Kilenyi, Blackie, 1992.