Sonic lasso catches cells
Press release issued: 3 April 2013
Academics in the University of Bristol’s Department of Mechanical Engineering and the University of Dundee's Institute for Medical Science and Technology have demonstrated for the first time that a “sonic lasso” can be used to grip microscopic objects, such as cells, and move them about.
The researchers have shown experimentally how tiny particles, such as cells, or any small objects can be trapped by a spinning ultrasonic, or sonic, vortex. The vortex acts as a lasso that can be controlled and moved, catching the microscopic particles and enabling their careful positioning.
This new technology makes possible applications such as assembly human tissue from a collection of cells and assembling nano materials.
Bruce Drinkwater, Professor of Ultrasonics in the Department of Mechanical Engineering and who led the study, said: “Our research has shown we can grip and move particles pretty much anywhere and along any path. The impressive thing is that it is completely non-contact, harmless and so ideal for moving delicate things, such as cells, around under a microscope. With further development this could be used to assemble human tissue as part of a tissue engineering production line.”
The paper explains that acoustic vortices, known as Bessel-functions, can be used to trap and controllably position microparticles. Like a rope lasso, the waves carry linear and rotational momentum and so can cause the objects to spin as well as move. A circular device, made up of 16 ultrasound sources, generates and manipulates an acoustic field within a chamber, trapping microparticles and clusters of microparticles. Changes in the phase of the sinusoidal signals applied to the sources result in the movement of the Bessel-function pressure field and therefore the microparticles.
This research has been funded by the Engineering and Physical Sciences Research Council (EPSRC) through the Electronic Sonotweezers programme.
Paper: Dexterous manipulation of microparticles using Bessel-function acoustic pressure fields, Charles Courtney (Bristol), Bruce Drinkwater (Bristol), Christine Demore (Dundee), Sandy Cochran (Dundee), Alon Grinenko (Bristol), Paul Wilcox (Bristol), Applied Physics Letters, published online April 2013.
Further informationAbout the Engineering and Physical Science Research Council (EPSRC)
The Engineering and Physical Sciences Research Council (EPSRC) is the UK’s main agency for funding research in engineering and the physical sciences. EPSRC invests around £800 million a year in research and postgraduate training, to help the nation handle the next generation of technological change. The areas covered range from information technology to structural engineering, and mathematics to materials science. This research forms the basis for future economic development in the UK and improvements for everyone’s health, lifestyle and culture. EPSRC works alongside other Research Councils with responsibility for other areas of research. The Research Councils work collectively on issues of common concern via Research Councils UK.